Title: Project 9

Project 9 (University of Bonn)

Metachromatic leukodystrophy: Strategies for substrate reduction therapy and investigations on neuronal and myelin pathology in new mouse models

This project will develop procedures for screening for inhibitors of the sulfatide synthesizing enzyme. Goal is the development of therapeutically active compounds which reduce the sulfatide load in this disease. Another part of this project will examine recently developed improved mouse models of MLD with particular respect to the effects neuronal storage and myelin pathology occurring in this disease.


Matthias Eckhardt, Volkmar Gieselmann, Heinz Beck


Dr. Matthias Eckhardt

Institut für Biochemie und Molekularbiologie

Universität Bonn

Nussallee 11

D-53115 Bonn

Phone +49 (0) 228 734735 / 4742

Fax +49 (0) 228 732416

Email eckhardt@institut.physiochem.uni-bonn.de

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