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Current Projects

 

Project 1

Epidemiology and description of the natural course of metachromatic leukodystrophy and globoid-cell leukodystrophy (Krabbe disease) manifesting during childhood and adolescence

 

Project 2

Characterization of cerebral alterations in children with unclassified and rare classified leukodystrophies using multiparametric magnetic resonance investigations

 

Project 3

Epidemiology and natural course of newly defined leukodystrophies with childhood onset: Clinical, neuroradiological, neurophysiological and genetic data

 

Project 4

Phenotypic variability, natural history and progression markers of late-onset leukodystrophies

 

Project 5

Cellular therapy of MLD based on combined transplantation of hematopoietic stem cells and multipotent mesenchymal stromal cells

 

Project 6

The rote of RNASET2 in the pathogenesis of cystic leukoencephalopathy without megalencephaly and in CNS myelination

 

Project 7

Molecular mechanisms of axonal degeneration in mouse models of human leukodystrophies

 

Project 9

Metachromatic leukodystrophy: Strategies for substrate reduction therapy and investigations an neuronal and myelin pathology in new mouse models

 

Project 10

Mutational analysis and rescue of arylsulfatase A and galactocerebrosidase activity by protease inhibitors as a novel therapeutic approach for metachromatic leukodystrophy and globoid cell leukodystrophy

 

Project 11

Coordination and administration of the network

 

 



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