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Current Projects


Project 1

Epidemiology and description of the natural course of metachromatic leukodystrophy and globoid-cell leukodystrophy (Krabbe disease) manifesting during childhood and adolescence


Project 2

Characterization of cerebral alterations in children with unclassified and rare classified leukodystrophies using multiparametric magnetic resonance investigations


Project 3

Epidemiology and natural course of newly defined leukodystrophies with childhood onset: Clinical, neuroradiological, neurophysiological and genetic data


Project 4

Phenotypic variability, natural history and progression markers of late-onset leukodystrophies


Project 5

Cellular therapy of MLD based on combined transplantation of hematopoietic stem cells and multipotent mesenchymal stromal cells


Project 6

The rote of RNASET2 in the pathogenesis of cystic leukoencephalopathy without megalencephaly and in CNS myelination


Project 7

Molecular mechanisms of axonal degeneration in mouse models of human leukodystrophies


Project 9

Metachromatic leukodystrophy: Strategies for substrate reduction therapy and investigations an neuronal and myelin pathology in new mouse models


Project 10

Mutational analysis and rescue of arylsulfatase A and galactocerebrosidase activity by protease inhibitors as a novel therapeutic approach for metachromatic leukodystrophy and globoid cell leukodystrophy


Project 11

Coordination and administration of the network



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